Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0774LY-F(E))
CAT#: HPAB-0774LY-F(E)
This product is a recombinant human antibody Fab fragment that recognizes PVRIG. The antibody was purified by affinity chromatography.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoli & endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/1365_E3_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glial cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_4_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47497/106259_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (Daudi, JURKAT, MOLT-4, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000213413-PVRIG/subcellular
❮
❯
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Human Fab
- Specificity
- Human PVRIG
- Species Reactivity
- Human
- Applications
- ELISA, FC, WB, Block
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD112R; C7orf15
- Gene ID
- 79037
REVIEWS AND Q&AS
CITATIONS
RESOURCES
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Exceptional Versatility
The Human Anti-PVRIG Fab fragment has become a staple in our lab for its versatility. Its application in ELISA, flow cytometry, and WB has greatly facilitated our research into immune checkpoints. The high purity ensures reliable data, minimizing background noise that we encountered with other antibodies.
Facilitates Detailed Flow Analysis
Our team found this antibody particularly useful for detailed flow cytometry analysis, documenting nuanced changes in immune cell populations. This accuracy is essential for our studies targeting checkpoint regulations.
Promising in Cancer Research
We've observed promising applications for this antibody in deciphering immune checkpoints in melanoma studies. Its precision in targeting and its role in uncovering PVRIG dynamics are shaping the future of our research projects.
Q&As
-
In what applications can this antibody be used?
A: This antibody is suitable for applications like ELISA, flow cytometry (FC), Western blot (WB), and blocking experiments. Its versatility makes it a valuable tool for protein analysis and interaction studies in laboratory settings.
-
What is the target of this antibody?
A: The Human Anti-PVRIG Recombinant Antibody targets PVRIG, a protein involved in immune checkpoints. This makes it significant in studying mechanisms related to immune response in cancer research, where PVRIG can act as a regulatory molecule on T cells.
-
What is the significance of blockading PVRIG in cancer therapies?
A: Blockading PVRIG may enhance T-cell activity, thus potentially boosting antitumor responses. This approach can contribute to the development of combination therapies involving other checkpoint inhibitors.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PVRIG"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0774LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0774LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| HPAB-0775LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0775LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| HPAB-0776LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0776LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| HPAB-0777LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0777LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| HPAB-0778LY-S(P) | Human Anti-PVRIG Recombinant Antibody; scFv Fragment (HPAB-0778LY-S(P)) | ELISA, FC, WB, Block | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0774LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0774LY) | ELISA, FC, WB, Block | Human IgG |
| HPAB-0775LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0775LY) | ELISA, FC, WB, Block | Human IgG |
| HPAB-0776LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0776LY) | ELISA, FC, WB, Block | Human IgG |
| HPAB-0777LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0777LY) | ELISA, FC, WB, Block | Human IgG |
| HPAB-0778LY | Human Anti-PVRIG Recombinant Antibody (HPAB-0778LY) | ELISA, FC, WB, Block | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0775LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0775LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
| HPAB-0776LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0776LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
| HPAB-0777LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0777LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
| HPAB-0778LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0778LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
| HPAB-0779LY-F(E) | Human Anti-PVRIG Recombinant Antibody; Fab Fragment (HPAB-0779LY-F(E)) | ELISA, FC, WB, Block | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC456 | Recombinant Anti-PVRIG Vesicular Antibody, EV Displayed (VS-0425-YC456) | Block, ELISA, FC, Cell-uptake |
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