Disease related genes, FDA approved drug targets, Human disease related genes
Secreted
Cell type enhanced (Collecting duct cells, B-cells)
Not detected in immune cells
Group enriched (HaCaT, SuSa)
Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
Heparin-binding
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For Research Use Only. Not For Clinical Use.