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SUFU
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
May form homodimers (PubMed:10564661). Part of a DNA-bound corepressor complex containing SAP18, GLI1 and SIN3 (By similarity). Part of a complex containing CTNNB1 (By similarity). Binds BTRC, GLI2, GLI3, SAP18 and STK36 (PubMed:10564661, 10806483). Binds both free and DNA-bound GLI1 (PubMed:10559945, 15367681, 24217340, 24311597, 28965847). Interacts with KIF7 (By similarity). Interacts with GLI3FL and this interaction regulates the formation of either repressor or activator forms of GLI3 (PubMed:24311597, 28965847). Its association with GLI3FL is regulated by Hh signaling and dissociation of the SUFU-GLI3 interaction requires the presence of the ciliary motor KIF3A (PubMed:24311597, 28965847). Interacts with ULK3; inactivating the protein kinase activity of ULK3 (PubMed:20643644). Interacts with RAB23 (PubMed:22365972).
Molecular function
Developmental protein
More Types Infomation
Related Signaling Pathways
Hedgehog Signaling Pathway
JAK-STAT Signaling Pathway
Related Diseases
Pancreatic Cancer
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, IHC-P, IP, WB
- Rabbit Anti-SUFU Polyclonal Antibody (MRO-2204-CN) (MRO-2204-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
- Mouse Anti-SUFU Recombinant Antibody (VS3-WK1218) (VS3-WK1218)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
- Rabbit Anti-SUFU Recombinant Antibody (VS3-WK1217) (VS3-WK1217)
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IHC, IF
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For Research Use Only. Not For Clinical Use.