TNFRSF10B
Anti-TNFRSF10B Recombinant Antibody Products
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- Target: DR5
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Target: DR5
- Linker: VC (valine-citrulline)
- Drug: MMAF (Monomethyl auristatin F)
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.