Plasma proteins
Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Homodimer and homotrimer; in response to cyclic AMP or calcium (PubMed:30061676). Interacts with hexokinases including HK1 (PubMed:8420959, PubMed:22304920). The HK1-VDAC1 complex interacts with ATF2 (PubMed:22304920). Interacts with BCL2L1 (PubMed:18755977, PubMed:25296756). Interacts with BAK1 (PubMed:25296756). Interacts with RTL10/BOP (via BH3 domain) (PubMed:23055042). Interacts with amyloid-beta and APP; induces VDAC1 dephosphorylation (PubMed:25168729). Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF (PubMed:26387735). Interacts with SPG7, NIPSNAP2 and SLC25A30 (PubMed:26387735). Interacts with TMEM41B (PubMed:30352685). Interacts with BCAP31 (PubMed:31206022). (Microbial infection) Interacts with influenza A virus PB1-F2 protein.
Porin
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For Research Use Only. Not For Clinical Use.