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ACTN1

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Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
FC, ICC/IF, IP, WB
Scaffold Name:
PDZ domain
Target:
α-actinin
Species Reactivity:
Human
Derivation:
Yeast Two-hybrid
Species Reactivity:
Human
Type:
Mouse antibody
Application:
ICC/IF, IHC, WB
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
RIA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
Neut, WB, FuncS
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