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  • Anti-Human SOD1 Therapeutic Single Domain Antibody (TAB-465CT)

Anti-Human SOD1 Therapeutic Single Domain Antibody (TAB-465CT) (CAT#: TAB-465CT)

Recombinant single domain antibody specifically binds to human SOD1. It could block fibril formation by SODl and reduce SODl aggregation in HeLa cells. The single domain antibody is particularly envisaged for treatment of ALS.


See more Engineered Antibody products for SOD1
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  • Gene Expression
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  • COA
Subcellular Location and Protein Expression
Figure 1 IHC staining of human cerebral cortex
Figure 1 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in glial cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8670/ihc_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/30_D2_1_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/29_D2_1_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/31_D2_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_B_9_5.jpg
Figure 6 Colon
Figure 6 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_7_3.jpg
Figure 7 Liver
Figure 7 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_8_4.jpg
Figure 8 Kidney
Figure 8 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_7_5.jpg
Figure 9 Testis
Figure 9 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_4_6.jpg
Figure 10 Lymph node
Figure 10 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_8_8.jpg
RNA Expression
Figure 11 RNA cell line category: Low cell line specificity
Figure 11 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142168-SOD1

Specifications

  • Immunogen
  • Human SOD1
  • Host Species
  • Llama
  • Type
  • Single domain antibody
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • TAB-465CT
  • Applications
  • Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Western Blot; Immunohistochemistry; Immunoprecipitation
  • Related Disease
  • Amyotrophic lateral sclerosis (ALS)

Target

  • Alternative Names
  • SOD1; superoxide dismutase 1; soluble; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; superoxide dismutase [Cu-Zn]; SOD; soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase; cystolic; epididymis secretory protein Li 44; anti-SOD1

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "SOD1"

Single-domain Antibody

CAT Product Name Application Type
NAB-1217-VHH Recombinant Anti-human SOD1 VHH Single Domain Antibody Neut, ChiP, IP, FUNC Llama VHH
MD-ZBF-YC020 Camelid Anti-SOD1 Recombinant Single Domain Antibody (MD-ZBF-YC020) WB, IP, IHC, ELISA Camelid VHH
MD-ZBF-YC021 Camelid Anti-SOD1 Recombinant Single Domain Antibody (MD-ZBF-YC021) WB, IP, IHC, ELISA Camelid VHH
MD-ZBF-YC022 Camelid Anti-SOD1 Recombinant Single Domain Antibody (MD-ZBF-YC022) WB, IP, IHC, ELISA Camelid VHH
MD-ZBF-YC023 Camelid Anti-SOD1 Recombinant Single Domain Antibody (MD-ZBF-YC023) WB, IP, IHC, ELISA Camelid VHH

Recombinant Antibody

CAT Product Name Application Type
MOB-1320z Mouse Anti-SOD1 Recombinant Antibody (clone 22C6) ELISA, FC, ICC, IF, WB Mouse IgG1
ZG-0574U Rabbit Anti-SOD1 Recombinant Antibody (clone 3E5) ELISA, WB, FC Rabbit IgG
VS3-FY1370 Recombinant Rabbit Anti-SOD1 Antibody (clone R04-4C6) WB, IHC-Fr, IHC-P, ICC, IF Rabbit IgG
VS3-FY1371 Recombinant Rabbit Anti-SOD1 Antibody (clone R07-1G6) WB, IHC-P Rabbit IgG
VS-0923-FY138 Recombinant Mouse Anti-SOD1 Antibody (VS-0923-FY138) ELISA, WB Mouse IgG1

Mouse Antibody

CAT Product Name Application Type
TAB-466CT Mouse Anti-SOD1 Recombinant Antibody (TAB-466CT) WB Mouse IgG
TAB-467CT Mouse Anti-SOD1 Recombinant Antibody (TAB-467CT) WB, IF Mouse IgG
TAB-466CT-S(P) Mouse Anti-SOD1 Recombinant Antibody; scFv Fragment (TAB-466CT-S(P)) ELISA, WB, BL, IHC Mouse scFv
TAB-467CT-S(P) Mouse Anti-SOD1 Recombinant Antibody; scFv Fragment (TAB-467CT-S(P)) ELISA, WB, BL, IHC Mouse scFv
TAB-468CT-S(P) Mouse Anti-SOD1 Recombinant Antibody; scFv Fragment (TAB-468CT-S(P)) ELISA, WB, BL, IHC Mouse scFv

Human Antibody

CAT Product Name Application Type
TAB-469CT Human Anti-SOD1 Recombinant Antibody (TAB-469CT) ELISA Human antibody
TAB-470CT Human Anti-SOD1 Recombinant Antibody (TAB-470CT) ELISA Human antibody
TAB-471CT Human Anti-SOD1 Recombinant Antibody (TAB-471CT) ELISA Human antibody
TAB-472CT Human Anti-SOD1 Recombinant Antibody (TAB-472CT) ELISA Human antibody
TAB-473CT Human Anti-SOD1 Recombinant Antibody (TAB-473CT) IF, ELISA Human IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3369 Hi-Affi™ Recombinant Rabbit Anti-SOD1 Monoclonal Antibody (DS3369AB) ICC/IF, IHC-P, IP, WB IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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