This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human IgE. Omalizumab is a recombinant DNA-derived humanized IgG1k monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Unlike an ordinary anti-IgE antibody, omalizumab does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. IgE is commonly involved in type I hypersensitivity, which manifests the most prevalent allergic diseases. It has been estimated that as high as 20 to 40% of the populations who live a western lifestyle in economically advanced countries are affected by allergy and seek medical help. In the U.S., 8% of adults and 10% of children have asthma. While allergy occurs more frequently in individuals with higher serum IgE levels, such a correlation is only statistical and not absolute. Some allergic individuals have very low serum IgE, and some people with very high IgE have no allergic problems.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Anti-Human IGHE Recombinant Antibody (Omalizumab)Recombinant monoclonal antibody to Human IgE. Omalizumab is a recombinant DNA-derived humanized IgG1k monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Unlike an ordinary anti-IgE antibody, omalizumab does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. IgE is commonly involved in type I hypersensitivity, which manifests the most prevalent allergic diseases. It has been estimated that as high as 20 to 40% of the populations who live a western lifestyle in economically advanced countries are affected by allergy and seek medical help. In the U.S., 8% of adults and 10% of children have asthma. While allergy occurs more frequently in individuals with higher serum IgE levels, such a correlation is only statistical and not absolute. Some allergic individuals have very low serum IgE, and some people with very high IgE have no allergic problems.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1075z | Mouse Anti-IGHE Recombinant Antibody (clone 20G9) | WB, IP | Mouse IgG2a |
HPAB-0168-LSX | Mouse Anti-IGHE Recombinant Antibody (clone MaE10) | ELISA, FC | Mouse IgG1 |
VS-0322-LC94 | Rabbit Anti-IGHE Recombinant Antibody (clone rMaE11) | Block, ELISA | |
VS-0322-LC96 | Rabbit Anti-IGHE Recombinant Antibody (clone rTES-C21) | Block, ELISA | |
VS3-WK1515 | Mouse Anti-IGHE Recombinant Antibody (VS3-WK1515) | WB, ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NABL-092 | Recombinant Anti-human IGHE VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-755 | Anti-IGHE Recombinant Antibody (Ligelizumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
TAB-007 | Anti-Human IGHE Recombinant Antibody (Omalizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L061R | anti-IGHE immunotoxin (Fab)-RTA | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-256CQ | Human Anti-IGHE Recombinant Antibody (TAB-256CQ) | Agonist | Human IgG2, κ |
TAB-257CQ | Human Anti-IGHE Recombinant Antibody (TAB-257CQ) | Agonist | Human IgG2, κ |
TAB-256CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-256CQ-F(E)) | ELISA, FC, WB | Human Fab |
TAB-257CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-257CQ-F(E)) | ELISA, FC, WB | Human Fab |
TAB-258CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-258CQ-F(E)) | ELISA, FC, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0168-LSX-S(P) | Mouse Anti-IGHE Recombinant Antibody (clone MaE10); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-0169-LSX-S(P) | Mouse Anti-IGHE Recombinant Antibody (clone MAE11); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-0170-LSX-S(P) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); scFv Fragment | ELISA, FC | Humanized scFv |
HPAB-0171-LSX-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (HPAB-0171-LSX-S(P)) | ELISA, RIA | Human scFv |
HPAB-0028-YJ-S(P) | Human Anti-IGHE Recombinant Antibody (clone E26); scFv Fragment | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0170-LSX-F(E) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); Fab Fragment | ELISA, FC | Humanized Fab |
HPAB-0171-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0171-LSX-F(E)) | ELISA, RIA | Human Fab |
HPAB-0172-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0172-LSX-F(E)) | ELISA, RIA | Human Fab |
HPAB-0173-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0173-LSX-F(E)) | ELISA, RIA | Human Fab |
HPAB-0028-YJ-F(E) | Human Anti-IGHE Recombinant Antibody (clone E26); Fab Fragment | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-255 | Afuco™ Anti-IGHE ADCC Recombinant Antibody (Quilizumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut | ADCC enhanced antibody |
AFC-TAB-755 | Afuco™ Anti-IGHE ADCC Recombinant Antibody (Ligelizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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