anti-IGHE immunotoxin (Fab)-RTA (CAT#: AGTO-L061R)
This immunotoxin was achieved by conjugating/fusing the Anti-IGHE Fab to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells bearing the IgE isotype. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Allergy.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211891-IGHE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211891-IGHE
Figure 1 RNA cell line category: Cell line enriched (U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211891-IGHE
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211891-IGHE
Specifications
- Host Species
- Goat
- Species Reactivity
- Mouse
- Molecule Class
- Fab-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Allergy
Target
- Alternative Names
- IGHE; immunoglobulin heavy constant epsilon; IgE; Allergy; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 3497
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "IGHE"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-092 | Recombinant Anti-human IGHE VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-755 | Anti-IGHE Recombinant Antibody (Ligelizumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
| TAB-007 | Anti-Human IGHE Recombinant Antibody (Omalizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-256CQ | Human Anti-IGHE Recombinant Antibody (TAB-256CQ) | Agonist | Human IgG2, κ |
| TAB-257CQ | Human Anti-IGHE Recombinant Antibody (TAB-257CQ) | Agonist | Human IgG2, κ |
| TAB-258CQ | Human Anti-IGHE Recombinant Antibody (TAB-258CQ) | Agonist | Human IgG2, κ |
| TAB-256CQ-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (TAB-256CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-257CQ-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (TAB-257CQ-S(P)) | ELISA, FC, WB | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0168-LSX | Mouse Anti-IGHE Recombinant Antibody (clone MaE10) | ELISA, FC | Mouse IgG1 |
| HPAB-0169-LSX | Mouse Anti-IGHE Recombinant Antibody (clone MAE11) | ELISA, FC, SPR | Mouse IgG2 |
| VS-0322-LC94 | Rabbit Anti-IGHE Recombinant Antibody (clone rMaE11) | Block, ELISA | |
| VS-0322-LC96 | Rabbit Anti-IGHE Recombinant Antibody (clone rTES-C21) | Block, ELISA | |
| VS3-WK1515 | Mouse Anti-IGHE Recombinant Antibody (VS3-WK1515) | WB, ELISA | Mouse IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0168-LSX-S(P) | Mouse Anti-IGHE Recombinant Antibody (clone MaE10); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0169-LSX-S(P) | Mouse Anti-IGHE Recombinant Antibody (clone MAE11); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0170-LSX-S(P) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0171-LSX-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (HPAB-0171-LSX-S(P)) | ELISA, RIA | Human scFv |
| HPAB-0172-LSX-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (HPAB-0172-LSX-S(P)) | ELISA, RIA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0170-LSX-F(E) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0171-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0171-LSX-F(E)) | ELISA, RIA | Human Fab |
| HPAB-0172-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0172-LSX-F(E)) | ELISA, RIA | Human Fab |
| HPAB-0173-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0173-LSX-F(E)) | ELISA, RIA | Human Fab |
| HPAB-0028-YJ-F(E) | Human Anti-IGHE Recombinant Antibody (clone E26); Fab Fragment | ELISA | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-007 | Afuco™ Anti-IGHE ADCC Recombinant Antibody (Omalizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
| AFC-TAB-255 | Afuco™ Anti-IGHE ADCC Recombinant Antibody (Quilizumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut | ADCC enhanced antibody |
| AFC-TAB-755 | Afuco™ Anti-IGHE ADCC Recombinant Antibody (Ligelizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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