anti-IGHE immunotoxin (Fab)-RTA
CAT#: AGTO-L061R
This immunotoxin was achieved by conjugating/fusing the Anti-IGHE Fab to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells bearing the IgE isotype. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Allergy.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211891-IGHE
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Specifications
- Host Species
- Goat
- Species Reactivity
- Mouse
- Molecule Class
- Fab-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Allergy
Target
- Alternative Names
- IGHE; immunoglobulin heavy constant epsilon; IgE; Allergy; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 3497
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| TAB-256CQ | Human Anti-IGHE Recombinant Antibody (TAB-256CQ) | Agonist | Human IgG2, κ |
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| TAB-257CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-257CQ-F(E)) | ELISA, FC, WB | Human Fab |
| TAB-258CQ-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (TAB-258CQ-F(E)) | ELISA, FC, WB | Human Fab |
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| HPAB-0168-LSX | Mouse Anti-IGHE Recombinant Antibody (clone MaE10) | ELISA, FC | Mouse IgG1 |
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| HPAB-0171-LSX | Human Anti-IGHE Recombinant Antibody (HPAB-0171-LSX) | ELISA, RIA | Human IgG |
| HPAB-0172-LSX | Human Anti-IGHE Recombinant Antibody (HPAB-0172-LSX) | ELISA, RIA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0168-LSX-S(P) | Mouse Anti-IGHE Recombinant Antibody (clone MaE10); scFv Fragment | ELISA, FC | Mouse scFv |
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| HPAB-0170-LSX-S(P) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); scFv Fragment | ELISA, FC | Humanized scFv |
| HPAB-0171-LSX-S(P) | Human Anti-IGHE Recombinant Antibody; scFv Fragment (HPAB-0171-LSX-S(P)) | ELISA, RIA | Human scFv |
| HPAB-0028-YJ-S(P) | Human Anti-IGHE Recombinant Antibody (clone E26); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0170-LSX-F(E) | Human Anti-IGHE Recombinant Antibody (clone 235-5.2); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-0171-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0171-LSX-F(E)) | ELISA, RIA | Human Fab |
| HPAB-0172-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0172-LSX-F(E)) | ELISA, RIA | Human Fab |
| HPAB-0173-LSX-F(E) | Human Anti-IGHE Recombinant Antibody; Fab Fragment (HPAB-0173-LSX-F(E)) | ELISA, RIA | Human Fab |
| HPAB-0028-YJ-F(E) | Human Anti-IGHE Recombinant Antibody (clone E26); Fab Fragment | ELISA | Humanized Fab |
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| AFC-TAB-007 | Afuco™ Anti-IGHE ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-007) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
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| AFC-TAB-755 | Afuco™ Anti-IGHE ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-755) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY120 | Human Anti-IGHE (clone Omalizumab) scFv-Fc Chimera | ELISA, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
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| VS-0425-YC368 | Recombinant Anti-IGHE Vesicular Antibody, EV Displayed (VS-0425-YC368) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY3456 | Anti-Sheep IGHE Immunohistochemistry Kit | IHC | |
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