Cancer-related genes, Human disease related genes
Intracellular
Cell type enhanced (NK-cells, Syncytiotrophoblasts)
Low immune cell specificity
Cell line enhanced (MOLT-4, REH)
Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex (PubMed:9106657, PubMed:19237555, PubMed:8114739). The cyclin subunit imparts substrate specificity to the complex (PubMed:8114739). Interacts with ATF5 (PubMed:15358120). Interacts with EIF3K (PubMed:15327989). Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity (PubMed:16782892). Can form similar complexes with either CDKN1A or CDKN2A (PubMed:9106657, PubMed:16782892).
Cyclin
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For Research Use Only. Not For Clinical Use.