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ROCK2
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Homodimer (By similarity). Interacts with IRS1 (By similarity). Interacts with RAF1 (By similarity). Interacts with RHOA (activated by GTP), RHOB and RHOC (By similarity). Interacts with PPP1R12A (PubMed:10579722, PubMed:19131646). Interacts with EP300 (PubMed:16574662). Interacts with CHORDC1 (PubMed:20230755). Interacts with BRCA2 (PubMed:21084279). Interacts with NPM1; this interaction enhances ROCK2 activity (PubMed:17015463). Interacts with SORL1 (PubMed:21147781). Interacts with PJVK (By similarity).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
- Recombinant Mouse Anti-Human ROCK2 Antibody (MOB-1277MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, IHC-P, IP, WB
- Rabbit Anti-ROCK2 Polyclonal Antibody (MRO-2168-CN) (MRO-2168-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ELISA, WB, IF
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For Research Use Only. Not For Clinical Use.