FDA approved drug targets, G-protein coupled receptors
Membrane
Cell type enhanced (Bipolar cells, Smooth muscle cells, Enteroendocrine cells, Sertoli cells)
Immune cell enhanced (basophil)
Cell line enriched (SCLC-21H)
Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
G-protein coupled receptor, Receptor, Transducer
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For Research Use Only. Not For Clinical Use.