Recombinant Human Anti-SSTR2 Antibody (clone 7A9) (CAT#: VS4-CJ126)

• Immunogen
• Recombinant Human SSTR2 protein

• Host Species
• Human

• Type
• Human IgG1

• Specificity
• Human SSTR2

• Species Reactivity
• Human

• Clone
• 7A9

• Applications
• ELISA, FC

• Conjugate
• Unconjugated

• Purification
• Affinity chromatography

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Buffer
• 50% Glycerol, 0.01M PBS, pH 7.4.

• Preservative
• 0.03% Proclin 300

• Storage
• Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

• Application Notes
• This antibody has been tested for use in ELISA, Flow Cytometry.

• Alternative Names
• SST2

• Gene ID
• 6752

• UniProt ID
• P30874

• Long Name
• Somatostatin receptor 2

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family.

• Cellular Localization
• Cell membrane, Cytoplasm, Membrane

• Post Translation Modifications
• Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).

• Protein Refseq
• NP_001041.1

• Function
• Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Isotype Control

• MRO-A1587-YJ
• Human IgG Isotype control, Polyclonal

Secondary Antibody

• 2RD-A1571-YJ
• Rabbit Anti-Human IgG1 Secondary antibody (Clone RM117)

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS