Loading...
CASP6
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
Protein class
Cancer-related genes, Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Granulosa cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Karpas-707)
Interaction
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunits (PubMed:19133298, PubMed:19694615, PubMed:20890311). Interacts with BIRC6/bruce (PubMed:15200957). Interacts with RIPK3 (PubMed:32298652). [Caspase-6 subunit p18]: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit. [Caspase-6 subunit p11]: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
Molecular function
Hydrolase, Protease, Thiol protease
More Types Infomation
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, IP
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, IF, IHC-P, WB
- Rabbit Anti-CASP6 Recombinant Antibody (clone CBACN-092) (MRO-0243-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
- Rabbit Anti-CASP6 Recombinant Antibody (clone CBACN-091) (MRO-0242-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
- Mouse Anti-CASP6 Recombinant Antibody (clone 4G63) (MOB-0329CT)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IP, WB
- Rabbit Anti-CASP6 Recombinant Antibody (VS3-CJ1046) (VS3-CJ1046)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, IP, FC
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.