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DKK3
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
Protein class
Plasma proteins
Predicted location
Secreted
Single cell type specificity
Group enriched (Muller glia cells, Cardiomyocytes)
Immune cell specificity
Immune cell enhanced (MAIT T-cell, memory CD8 T-cell)
Cell line specificity
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, hTERT-RPE1, TIME)
Interaction
Interacts with LRP5 and LRP6.
Molecular function
Developmental protein
More Types Infomation
Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
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- Species Reactivity: Human
- Application: ELISA, FC, WB
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
- Mouse Anti-DKK3 Recombinant Antibody (HPAB-2833LY) (HPAB-2833LY)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, Block
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IP
- Mouse Anti-DKK3 Recombinant Antibody; scFv Fragment (HPAB-2833LY-S(P)) (HPAB-2833LY-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, Block
- Mouse Anti-DKK3 Recombinant Antibody (clone 4G7) (VS3-QX326)
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- Derivation: Mouse
- Species Reactivity: Human, Monkey
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
- Mouse Anti-DKK3 Recombinant Antibody; Fab Fragment (HPAB-2833LY-F(E)) (HPAB-2833LY-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, Block
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
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For Research Use Only. Not For Clinical Use.