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SMAD5

Engineered Antibody
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Low cell line specificity

Interaction

May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. Interacts with TMEM119 (By similarity). Interacts with ZNF8 (PubMed:12370310). Interacts with RANBP3L (PubMed:25755279).

Molecular function

DNA-binding

More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway TGF-β Signaling Pathway

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