Anti-HIV-1 antibody is a Human antibody of IgG class that binds to an HIV-1.
Figure 1 ADCC assay using cells infectedwithHIV-1 BaL IMC.
EGFP-CEM-NKr-CCR5-SNAP cellswere spinoculatedwith HIV-1 Balmolecular clone at 2000 rpmfor 2 h at 12 °C.
Orlandi, C., Flinko, R., & Lewis, G. K. (2016). A new cell line for high throughput HIV-specific antibody-dependent cellular cytotoxicity (ADCC) and cell-to-cell virus transmission studies. Journal of immunological methods, 433, 51-58.
Figure 2 Flow cytometry analysis.
After 5 days of co-culturewith the virus, cellswerewashed twice, labeled with Alexa Fluor 647-SNAP tag dye and incubated with dilutions ofmAbs (C11, N5-i5,N10-U1 or Synagis) for 15min at RT, then PBMC were added to the reaction for 3 h at 37 °C. At the end of the incubation, the samples were washed with PBS, fixed with 1% paraformaldehyde and analyzed by flow cytometry. The ADCC data represent the typical results obtained in three independent experiments. Upper right panel. The efficiency of the infection was evaluated by staining of the cells with live/dead (not shown), CD4-APC and p24-PE. Lower right panel. Binding of infected EGFP-CEM-NKr-CCR5-SNAP cells with 5 μg/ml Alexa Fluor-647-conjugated mAbs C11 (panel A), N5-i5 (panel B) or N10U1 (panel C).
Orlandi, C., Flinko, R., & Lewis, G. K. (2016). A new cell line for high throughput HIV-specific antibody-dependent cellular cytotoxicity (ADCC) and cell-to-cell virus transmission studies. Journal of immunological methods, 433, 51-58.
Figure 3 Crystal structures of the N5-i5 Fab-gp12093TH057 coree-d1d2CD4 and 2.2c Fab-gp12089.6P coree-d1d2CD4 complexes.
The light/heavy chains of N5-i5 Fab and 2.2c Fab are shown in light blue/dark blue and light pink/dark pink, respectively, and the complementarity-determining regions (CDRs) are shown in black (CDR L1), brown (CDR L2), light blue (CDR L3), gray (CDR H1), green (CDR H2), and cyan (CDR H3). The gp120 inner domain is shown in yellow, and the outer domain is in orange. See also Fig. S1A in the supplemental material.
Acharya, P., Tolbert, W. D., Gohain, N., Wu, X., Yu, L., Liu, T., ... & Luongo, T. S. (2014). Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection. Journal of virology, 88(21), 12895-12906.
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CAT | Product Name | Application | Type |
---|---|---|---|
NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-209 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L3); scFv Fragment | Neut | Human scFv |
PSBZ-210 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 19.3H-L1); scFv Fragment | Neut | Human scFv |
FAMAB-0177CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone BAT123); Fab Fragment | Neut | Chimeric (mouse/human) Fab |
FAMAB-0178CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone C beta 1); Fab Fragment | WB, Neut | Chimeric (mouse/human) Fab |
MRO-2927CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 1-74); Fab Fragment | Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (D59/A2) | ELISA | Mouse antibody |
MRO-042LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (F58/H3) | ELISA | Mouse antibody |
MRO-043LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P1/D12) | ELISA | Mouse antibody |
MRO-044LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P4/D10) | ELISA | Mouse antibody |
MRO-045LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3431CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 559/64-D (559, 559-64D)) | Neut, ELISA | Human IgG1, κ |
MRO-3432CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 8AC454) | ELISA, FC | Human IgG |
MRO-3433CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 3BC241) | ELISA, FC | Human IgG |
MRO-3434CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 8AC117) | ELISA, FC | Human IgG |
MRO-3435CQ | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 8AC492) | ELISA, FC | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3592CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 8F101); scFv Fragment | ELISA, FC | Mouse scFv |
MRO-3593CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 2F2); scFv Fragment | ELISA | Mouse scFv |
MRO-3594CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 5E11); scFv Fragment | ELISA | Mouse scFv |
MRO-3595CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 7H3); scFv Fragment | ELISA | Mouse scFv |
MRO-3645CQ-S(P) | Rat Anti-HIV-1 gp120 Recombinant Antibody (clone ICR 39.3b (39.3, 39.3b, ICR39.3b)); scFv Fragment | Neut | Rat scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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