Anti-HIV-1 gp120 Recombinant Antibody (N6) (CAT#: MRO-125LC)
This product is a recombinant human anti-HIV-1 monoclonal antibody (N6). N6 specifically binds to gp120 and can be potentially used in the treatment studies of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
Specific Inquiry
Neut
Figure 1. Neutralization potency and breadth of N6, in comparison to other bNAbs, against a 181-isolate Env-pseudovirus panel.
N6 neutralized 98% of 181 pseudoviruses at an IC50 < 50 μg/mL.
Huang, J., Kang, B. H., Ishida, E., Zhou, T., Griesman, T., Sheng, Z., ... & O’Dell, S. (2016). Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth. Immunity, 45(5), 1108-1121.
ELISA
Figure 2. ELISA binding of N6 to the indicated proteins.
Although VRC01 and VRC27 did not bind X2088, N6 bound it strongly. Unlike the other CD4bs antibodies tested by ELISA, N6 bound to CD4bs mutants: gp120 D368R and gp120 resurfaced stabilized core 3 (RSC3) Δ371I-P363N
Huang, J., Kang, B. H., Ishida, E., Zhou, T., Griesman, T., Sheng, Z., ... & O’Dell, S. (2016). Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth. Immunity, 45(5), 1108-1121.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- HIV-1
- Clone
- N6
- Applications
- Neut, ELISA
- Related Disease
- AIDS
Applications
- Application Notes
- The N6 antibody has been reported in applications of Neut, ELISA.
It's recommended that the optimal antibody concentration, dilution, incubation time etc. are best to be carefully titrated in specific assays. For details, refer to Published Data.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120; gp120; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone N6"
See other products for "HIV-1 gp120"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
| MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
| MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
| MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) | ELISA, Neut | Human IgG |
| PABL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d) | Neut, WB, ELISA, FuncS | Human IgG |
| PABL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) | WB, ELISA, FuncS | Mouse IgG1, κ |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
| MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
| MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
| MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
| MRO-139LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900974) | ELISA | Human antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
| MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
| MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-041LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (D59/A2) | ELISA | Mouse antibody |
| MRO-042LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (F58/H3) | ELISA | Mouse antibody |
| MRO-043LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P1/D12) | ELISA | Mouse antibody |
| MRO-044LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P4/D10) | ELISA | Mouse antibody |
| MRO-045LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (A47/B1) | ELISA | Mouse antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3397CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 9CL); Fab Fragment | ELISA | Human Fab |
| MRO-3398CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 1027-30-D (1027-30D, 1027/30D, 1027)); Fab Fragment | ELISA | Human Fab |
| MRO-3399CQ-F(E) | Recombinant Human Anti-HIV-1 gp120 Antibody Fab Fragment (2483) | Neut | Fab |
| MRO-3400CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 2580); Fab Fragment | Neut | Human Fab |
| MRO-3401CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 411g); Fab Fragment | ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-291 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 1A8); scFv Fragment | Neut | Human scFv |
| PSBC-292 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 1E12); scFv Fragment | Neut | Human scFv |
| FAMAB-0056WJ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L17); scFv Fragment | ELISA, Neut | Human scFv |
| FAMAB-0057WJ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L69); scFv Fragment | ELISA, Neut | Human scFv |
| FAMAB-0058WJ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone P20); scFv Fragment | ELISA, Neut | Human scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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