Anti-HIV-1 gp120 Recombinant Antibody (N6) (CAT#: MRO-125LC)
This product is a recombinant human anti-HIV-1 monoclonal antibody (N6). N6 specifically binds to gp120 and can be potentially used in the treatment studies of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Neut
Figure 1. Neutralization potency and breadth of N6, in comparison to other bNAbs, against a 181-isolate Env-pseudovirus panel.
N6 neutralized 98% of 181 pseudoviruses at an IC50 < 50 μg/mL.
Huang, J., Kang, B. H., Ishida, E., Zhou, T., Griesman, T., Sheng, Z., ... & O’Dell, S. (2016). Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth. Immunity, 45(5), 1108-1121.
ELISA
Figure 2. ELISA binding of N6 to the indicated proteins.
Although VRC01 and VRC27 did not bind X2088, N6 bound it strongly. Unlike the other CD4bs antibodies tested by ELISA, N6 bound to CD4bs mutants: gp120 D368R and gp120 resurfaced stabilized core 3 (RSC3) Δ371I-P363N
Huang, J., Kang, B. H., Ishida, E., Zhou, T., Griesman, T., Sheng, Z., ... & O’Dell, S. (2016). Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth. Immunity, 45(5), 1108-1121.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- HIV-1
- Clone
- N6
- Applications
- Neut, ELISA
- Related Disease
- AIDS
Applications
- Application Notes
- The N6 antibody has been reported in applications of Neut, ELISA.
It's recommended that the optimal antibody concentration, dilution, incubation time etc. are best to be carefully titrated in specific assays. For details, refer to Published Data.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120; gp120; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Humanized Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) | ELISA, Neut | Human IgG |
| PABL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d) | Neut, WB, ELISA, FuncS | Human IgG |
| PABL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) | WB, ELISA, FuncS | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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