Mouse Anti-TBEV Recombinant Antibody (clone 10C2) (CAT#: FAMAB-0133JF)

Recombinant monoclonal antibody specially binds to tick-borne encephalitis virus. This mouse anti-TBEV monoclonal antibody 10C2 could be potencially used in the treatment of Tick-borne encephalitis.


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WB

Figure 1 Western blot of a lysate of TBEV-infected cells was prepared.

Figure 1 Western blot of a lysate of TBEV-infected cells was prepared.

Reactivity of mouse sera with TBEV proteins.

Kreil, T. R., Maier, E., Fraiss, S., & Eibl, M. M. (1998). Neutralizing antibodies protect against lethal flavivirus challenge but allow for the development of active humoral immunity to a nonstructural virus protein. Journal of virology, 72(4), 3076-3081.

ELISA

Figure 2 Active immunity to TBEV. Female BALB/c mice were administered s.c. 0.2 ml of a 1:10-diluted human TBEV Ig preparation 2 h before they were injected i.p. with different amounts of TBEV.

Figure 2 Active immunity to TBEV. Female BALB/c mice were administered s.c. 0.2 ml of a 1:10-diluted human TBEV Ig preparation 2 h before they were injected i.p. with different amounts of TBEV.

Differences in the survival of groups of mice were compared to the survival of mice which received UV-inactivated TBEV instead of the initial TBEV challenge by a two-sided log-rank test, and significances are indicated by asterisks.

Kreil, T. R., Maier, E., Fraiss, S., & Eibl, M. M. (1998). Neutralizing antibodies protect against lethal flavivirus challenge but allow for the development of active humoral immunity to a nonstructural virus protein. Journal of virology, 72(4), 3076-3081.

IHC

Figure 3 Brain, thalamus, severe lymphohistiocytic perivascular infiltration of neuroparenchyma and gliosis.

Figure 3 Brain, thalamus, severe lymphohistiocytic perivascular infiltration of neuroparenchyma and gliosis.

Original magnification ×200.

Böhm, B., Schade, B., Bauer, B., Hoffmann, B., Hoffmann, D., Ziegler, U., ... & Böttcher, J. (2017). Tick-borne encephalitis in a naturally infected sheep. BMC veterinary research, 13(1), 267.


Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Tick-borne encephalitis virus
  • Species Reactivity
  • TBEV
  • Clone
  • 10C2
  • Applications
  • WB, ELISA, IHC
  • Related Disease
  • Tick-borne encephalitis

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The TBEV antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.

Target

  • Alternative Names
  • Tick-borne encephalitis virus; TBEV
  • Function
  • Neutralization

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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