GA-Pyridine

Glycolaldehyde (GA) is formed from serine by action of myeloperoxidase and reacts with proteins to form several products. Prominent among them is N(epsilon)-(carboxymethyl)lysine (CML), which is also known as one of the advanced glycation end products. Since CML is formed from a wide range of precursors, it has been attempted to identify unique structures characteristic of the reaction of GA with protein. In previous reports, the accumulation of GA-pyridine in human atherosclerotic lesions was detected by immunohistochemical staining with the anti-GA-pyridine monoclonal antibody clone 2A2 (Cosmo-Bio). The results showed that this antibody exhibited a reactivity to human atherosclerotic lesions similar to that of 2A2.