G-protein coupled receptors, Transporters
Intracellular, Membrane (different isoforms)
Cell type enhanced (Hepatocytes, Kupffer cells, Distal enterocytes, Endothelial cells, Adipocytes)
Group enriched (myeloid DC, classical monocyte, intermediate monocyte)
Cell line enhanced (AN3-CA, Daudi, fHDF/TERT166, Hep G2)
Homodimer (Probable). Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like CRHR1, HTR1A and PAQR8. Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity). Interacts with RAMP3. Interacts with KRT7 and KRT8. Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated fibroblasts (CAF). Interacts with EGFR and ESR1.
G-protein coupled receptor, Receptor, Transducer
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For Research Use Only. Not For Clinical Use.