Disease related genes, Transcription factors
Intracellular
Cell type enriched (dendritic cells)
Immune cell enriched (plasmacytoid DC)
Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, Karpas-707)
Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3 (PubMed:17574024). Interacts with TICAM1 and TICAM2. Interacts with MYD88 and TRAF6. Interacts with TRIM35 (PubMed:25907537, PubMed:11073981, PubMed:11314014, PubMed:14517278, PubMed:14739303, PubMed:15361868, PubMed:15492225). Interacts with NMI; the interaction is direct and leads to the inhibition of IRF7-mediated type I IFN production (By similarity). (Microbial infection) Interacts with Epstein-Barr virus LF2 and LMP1. (Microbial infection) Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7. (Microbial infection) Interacts with human herpes virus 8/HHV-8 proteins ORF45 and vIRF-1. (Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein HBZ. (Microbial infection) Interacts with Seneca Valley virus protease 3C; this interaction is involved in the suppression of IRF7 expression and phosphorylation by the virus. (Microbial infection) Interacts with ebolavirus VP35; this interaction mediates the sumoylation of IRF7 and contributes to the viral inhibition of IFN-type I production.
Activator, DNA-binding
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For Research Use Only. Not For Clinical Use.