Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets
Intracellular
Cell type enhanced (Spermatocytes, Spermatogonia)
Low immune cell specificity
Low cell line specificity
Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9 (PubMed:23401855, PubMed:26300262). Interacts with the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1 (PubMed:26300262). Interacts with RAD51; the interaction recruits RAD51 to DNA damage sites (PubMed:23401855). Interacts with the MRN complex composed of MRE11, RAD50 and NBN/NBS1 (PubMed:26215093). Interacts with CDC6 and ORC2 (PubMed:15684404). Interacts with HROB; the interaction recruits the MCM8-MCM9 complex to DNA damage sites (PubMed:31467087).
DNA-binding, Helicase, Hydrolase
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For Research Use Only. Not For Clinical Use.