Pyruvate kise isoenzyme type M2 (PKM2 or M2-PK) is one of the two isozymes encoded by the human PKM gene. The two isozymes M1 and M2 are altertive splicing products and differ in one of eleven exons. Pyruvate kise is a critical enzyme in glycolysis as it dephosphorylates phosphoenolpyruvate (PEP) to pyruvate resulting in the net production ATP.