Plasma proteins
Intracellular, Membrane (different isoforms)
Low cell type specificity
Group enriched (neutrophil, basophil)
Low cell line specificity
Homodimer (PubMed:19644450). The homodimer interacts with ARF6, forming a heterotetramer (PubMed:19644450). Homooligomer (PubMed:19644450). Interacts with MAX, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4 (By similarity). Interaction with KNS2 is important in the formation of ternary complex with MAPK8 (By similarity). Interacts with NFKB1 (PubMed:14743216). Interacts with PIP4P1 (PubMed:29146937). Interacts with PIKFYVE (By similarity). [Isoform 5]: Interacts with MAPK8, MAPK9, MAPK10.
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For Research Use Only. Not For Clinical Use.