Disease related genes, Human disease related genes
Intracellular, Membrane (different isoforms)
Cell type enhanced (Oligodendrocyte precursor cells, Microglial cells, Astrocytes, Excitatory neurons, Oligodendrocytes)
Immune cell enhanced (non-classical monocyte)
Low cell line specificity
Homodimer and heterodimer (PubMed:15683364). Able to interact with SPRED2 to form heterodimers (PubMed:15683364). Interacts (via C-terminus) with TAOK1/MARKK (via C-terminus); the interaction does not affect TAOK1 kinase activity (PubMed:18216281). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:18216281). Interacts with CAV1 (PubMed:16115197). Interacts with RAS (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction leads to palmitoylation of SPRED1 (PubMed:24705354).
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For Research Use Only. Not For Clinical Use.