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SPRED2
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
Protein class
Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Excitatory neurons, Oligodendrocyte precursor cells, Inhibitory neurons, Astrocytes)
Immune cell specificity
Group enriched (plasmacytoid DC, NK-cell)
Cell line specificity
Low cell line specificity
Interaction
Homodimer and heterodimer (PubMed:15683364). Able to interact with SPRED1 to form heterodimers (PubMed:15683364). Interacts with RAS (By similarity). May interact with ZDHHC13 (via ANK repeats) and ZDHHC17 (via ANK repeats) (By similarity). Interacts with TESK1 (By similarity).
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.