Recombinant Human Antibody (E317) is capable of binding to HHV-2 gD, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HHV-2 gD mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-HHV-2 gD proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The highly inhibitory human monoclonal antibody E317 was previously raised against HSV gD for viral neutralization. E317 directly recognizes the gD-nectin-1 interface and occludes the HVEM contact site of gD to block its binding to either receptor. The binding of E317 to gD also prohibits the formation of the N-terminal hairpin of gD for HVEM recognition.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PFBC-161 | Recombinant Human Anti-HHV-2 gD Antibody Fab Fragment (E317) | Neut | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-161 | Recombinant Human Anti-HHV-2 gD Antibody scFv Fragment (E317) | Neut | scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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