Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (JM7) (CAT#: MRO-4376CQ)
Recombinant Llama Antibody to gp120. JM7 exhibited subnanomolar affinity to the gp120/mini CD4 complex but doesn't bind to gp120 or gp120/sCD4 complex or the CD4 mimic alone. This could be explained through binding to a bimolecular epitope.
Specific Inquiry
ELISA
Figure 1 sdAb binding pattern on different conformations and strains of HIV-5 Env followed by ELISA.
JM7 only binds to the cross-linked Env.
Matz, J., Kessler, P., Bouchet, J., Combes, O., Ramos, O. H. P., Barin, F., ... & Chames, P. (2013). Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120. Journal of virology, 87(2), 1137-1149.
Inhib
Figure 2 Characterization of CD4BS sdAb.
Curves obtained by fluorescence polarization using a fluorescent miniCD4 M64-Fluo as probe in the presence of various concentrations of sdAbs and miniCD4 M48U1.
Matz, J., Kessler, P., Bouchet, J., Combes, O., Ramos, O. H. P., Barin, F., ... & Chames, P. (2013). Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120. Journal of virology, 87(2), 1137-1149.
ELISA
Figure 3 sdAb epitope mapping using Env mutants by ELISA.
Results are expressed as percentage of binding compared to WT gp140.
Matz, J., Kessler, P., Bouchet, J., Combes, O., Ramos, O. H. P., Barin, F., ... & Chames, P. (2013). Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120. Journal of virology, 87(2), 1137-1149.
Specifications
- Host Species
- Camelid
- Type
- Camelid VHH
- Specificity
- Recognizes HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- JM7
- Applications
- ELISA, Inhib
Product Property
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp120 Single Domain antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Inhibition.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120; gp120; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "HIV-1 gp120"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) | ELISA, Neut | Human IgG |
| PABL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d) | Neut, WB, ELISA, FuncS | Human IgG |
| PABL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) | WB, ELISA, FuncS | Mouse IgG1, κ |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
| MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
| MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
| MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
| MRO-032LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91H9) | ELISA | Single domain antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
| MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
| MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
| MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
| MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
| MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
| MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-041LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (D59/A2) | ELISA | Mouse antibody |
| MRO-042LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (F58/H3) | ELISA | Mouse antibody |
| MRO-043LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P1/D12) | ELISA | Mouse antibody |
| MRO-044LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P4/D10) | ELISA | Mouse antibody |
| MRO-045LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (A47/B1) | ELISA | Mouse antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3379CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone NIH45-46G54W (45-46W,NIH45-46W)); Fab Fragment | Neut | Human Fab |
| MRO-3380CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L25); Fab Fragment | Neut, ELISA | Human Fab |
| MRO-3381CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L19); Fab Fragment | ELISA | Human Fab |
| MRO-3382CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L81); Fab Fragment | ELISA | Human Fab |
| MRO-3383CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC26.08 (CAP256-VRC26.08)); Fab Fragment | Neut, ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0201CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone S20); scFv Fragment | ELISA, Neut | Human scFv |
| HPAB-S0049-YC-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 4022); scFv Fragment | ELISA | Human scFv |
| HPAB-S0050-YC-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 3792); scFv Fragment | ELISA | Human scFv |
| PSBS-0130 | Human Anti-HIV-1 gp120 Recombinant Antibody (Clone VRC01cHuGL2); scFv Fragment | ELISA, FuncS | Human scFv |
| PABJ-0086-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone DH677.3); scFv Fragment | ELISA, ADCC | Human scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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