Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) (CAT#: PABL-135)
Recombinant Human Antibody (PGT135) is capable of binding to HIV, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
Figure 1 Neutralization sensitivity of PGT135 against BaL wild-type pseudovirus and glycan site mutants.
Pritchard, L. K., Spencer, D. I., Royle, L., Vasiljevic, S., Krumm, S. A., Doores, K. J., & Crispin, M. (2015). Glycan microheterogeneity at the PGT135 antibody recognition site on HIV-1 gp120 reveals a molecular mechanism for neutralization resistance. Journal of virology, JVI-00230.
Figure 2 Enzyme-linked immunosorbent assay (ELISA) data of PGT135 (blue) and 2G12 (black) binding to wild-type (continuous line) and kifunensine-treated (dashed line) gp120.
Pritchard, L. K., Spencer, D. I., Royle, L., Vasiljevic, S., Krumm, S. A., Doores, K. J., & Crispin, M. (2015). Glycan microheterogeneity at the PGT135 antibody recognition site on HIV-1 gp120 reveals a molecular mechanism for neutralization resistance. Journal of virology, JVI-00230.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Type
- Human IgG
- Specificity
- HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- PGT135
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Neut and ELISA. For details, refer to published data.
Target
- Alternative Names
- HIV; AIDS; human immunodeficiency virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-184 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC27.01) | FC, Neut, FuncS | Human IgG |
| PABZ-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 50.1) | Neut | Mouse IgG2a, κ |
| PABW-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 58.2) | Neut | Mouse IgG1 |
| PABC-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 83.1) | Neut | Mouse IgG1 |
| PABZ-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 0.5β) | Neut | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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