Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) (CAT#: PABL-135)
Recombinant Human Antibody (PGT135) is capable of binding to HIV, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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Figure 1 Neutralization sensitivity of PGT135 against BaL wild-type pseudovirus and glycan site mutants.
Pritchard, L. K., Spencer, D. I., Royle, L., Vasiljevic, S., Krumm, S. A., Doores, K. J., & Crispin, M. (2015). Glycan microheterogeneity at the PGT135 antibody recognition site on HIV-1 gp120 reveals a molecular mechanism for neutralization resistance. Journal of virology, JVI-00230.
Figure 2 Enzyme-linked immunosorbent assay (ELISA) data of PGT135 (blue) and 2G12 (black) binding to wild-type (continuous line) and kifunensine-treated (dashed line) gp120.
Pritchard, L. K., Spencer, D. I., Royle, L., Vasiljevic, S., Krumm, S. A., Doores, K. J., & Crispin, M. (2015). Glycan microheterogeneity at the PGT135 antibody recognition site on HIV-1 gp120 reveals a molecular mechanism for neutralization resistance. Journal of virology, JVI-00230.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Type
- Human IgG
- Specificity
- HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- PGT135
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Neut and ELISA. For details, refer to published data.
Target
- Alternative Names
- HIV; AIDS; human immunodeficiency virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Humanized Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135); Fab Fragment | ELISA, Neut | Human Fab |
| PFBL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03); Fab Fragment | WB, ELISA, Neut, FuncS | Human Fab |
| PFBL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31); Fab Fragment | WB, ELISA, Neut, FuncS | Human Fab |
| PFBL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
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