Mouse Anti-MICA/B Recombinant Antibody (clone 13A9) (CAT#: PABC-517)
This product is a recombinant Mouse antibody that can recognize MICA/B. 13A9 displays strong shedding inhibition of MICA*002 and MICB*005.
Specific Inquiry
Inhib
Figure 1 Anti-MICA antibodies binned by traditional epitope competition experiments elicit a range of shedding inhibition.
59 anti-MICA antibodies that bind MICA*002, *004 and *008 and MICB*005 were characterized by competition binding studies. Orange depicts antibody clone 1D5, green 13A9 and blue 6E1.
Lombana, T. N., Matsumoto, M. L., Bevers III, J., Berkley, A. M., Toy, E., Cook, R., ... & Sandoval, W. (2019, January). High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies. In mAbs (Vol. 11, No. 1, pp. 75-93). Taylor & Francis.
FuncS
Figure 2 Anti-MIC 13A9 antibody can prevent MICA shedding in vitro and show anti-tumor activity in a prevention model in vivo.
Growth curves of individual HCC1534 tumors. Mice were treated with 10 mg/kg of anti-MIC 13A9 antibody following tumor cell inoculation. Gray shading indicates days of dosing range.
Lombana, T. N., Matsumoto, M. L., Bevers III, J., Berkley, A. M., Toy, E., Cook, R., ... & Sandoval, W. (2019, January). High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies. In mAbs (Vol. 11, No. 1, pp. 75-93). Taylor & Francis.
Specifications
- Immunogen
- MIC protein(s)
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human MICA/B
- Species Reactivity
- Human
- Clone
- 13A9
- Applications
- ELISA, Inhib
Product Property
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.
Target
- Alternative Names
- MICA; MICB; MHC class I polypeptide-related sequence A; MHC class I polypeptide-related sequence B
- Gene ID
- 100507436
- UniProt ID
- Q29983
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 13A9"
See other products for "MICA/B"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-516 | Mouse Anti-MICA/B Recombinant Antibody (clone 1D5) | ELISA | Mouse IgG2a |
| FN-173CQ | Recombinant Mouse Anti-MICA/B Antibody (6D4) | FC, FuncS, IHC, IP | Mouse IgG2a, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-516 | Mouse Anti-MICA/B Recombinant Antibody (clone 1D5); Fab Fragment | ELISA | Mouse Fab |
| PFBC-517 | Mouse Anti-MICA/B Recombinant Antibody (clone 13A9); Fab Fragment | ELISA, Inhib | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-516 | Mouse Anti-MICA/B Recombinant Antibody (clone 1D5); scFv Fragment | ELISA | Mouse scFv |
| PSBC-517 | Mouse Anti-MICA/B Recombinant Antibody (clone 13A9); scFv Fragment | ELISA, Inhib | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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