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CLDN10
CLDN10 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Ductal cells, Cholangiocytes, Proximal tubular cells, Club cells, Glandular and luminal cells, Basal respiratory cells)
Immune cell specificity
Group enriched (neutrophil, eosinophil)
Cell line specificity
Cell line enhanced (HUVEC TERT2, NTERA-2, RPTEC TERT1, SuSa)
Interaction
Can form homodimers both in trans (interaction between CLDN10 molecules in opposing membranes) and in cis (interaction between CLDN10 molecules within one membrane).
More Types Infomation
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.