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EEA1

The EEA1 gene encodes a protein of 1400 amino acids, early endosomal antigen 1.

EEA1 is localized only in early endosomes and plays an important role in endosome transport. EEA1 directly binds phospholipid phosphatidylinositol 3-phosphate via its C-terminal FYVE domain, and forms a homodimer by coiling coils. EEA1 acts as a binding molecule, docking vesicles with SNARE (such as N-ethylmaleimide-sensitive fusion protein), bringing the endosome physically closer, and ultimately leading to the fusion and delivery of endosome cargo.

EEA1 is a RAB5A effector protein, which is bound by the N-terminal zinc finger domain and is necessary for early and late endosomal fusion and sorting at the early endosomal level.
Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Not detected in immune cells

Cell line specificity

Low cell line specificity

Interaction

Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with RAB31. Interacts with ERBB2. Interacts with SAMD9 AND SAMD9L (PubMed:24029230). May interact with PLEKHF2.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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