DEspR is a cell-membrane receptor that binds to endothelin-1, to VEGF signal peptide signal peptide 26 (VEGFsp-26/sp26), and to VEGF signal peptide 17 (VEGFsp-17/spl7). VEGFsp-26 has the human sequence MNFLLSWVHWSLALLLYLHHAKWSQA. VEGFsp-17 has the human sequence MNFLLSWVHWSLALLLY.