Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters
Membrane
Group enriched (Cone photoreceptor cells, Rod photoreceptor cells)
Immune cell enriched (plasmacytoid DC)
Cell line enriched (JURKAT)
Homodimer; requires homodimerization for guanylyl cyclase activity (By similarity). Interacts with RD3; promotes the exit of GUCY2D from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (PubMed:21928830, PubMed:21078983). Interaction with RD3 negatively regulates guanylate cyclase activity (PubMed:21928830).
Lyase
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For Research Use Only. Not For Clinical Use.