Plasma proteins
Intracellular
Cell type enhanced (Kupffer cells, Macrophages, monocytes, NK-cells, T-cells, B-cells)
Low immune cell specificity
Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-266/70, U-698)
Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS (By similarity). Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54 (By similarity).
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For Research Use Only. Not For Clinical Use.