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HDGFL2
This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Granulosa cells, Theca cells, Cytotrophoblasts, Endometrial stromal cells, Extravillous trophoblasts)
Immune cell specificity
Immune cell enhanced (naive B-cell)
Cell line specificity
Low cell line specificity
Interaction
Interacts with HDGF (By similarity). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Interacts with IWS1 (PubMed:25689719). Interacts with H2AX, POGZ, RBBP8 and CBX1 (PubMed:26721387). Interacts with histones H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Interacts with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Interacts with SMARCA4/BRG1/BAF190A, SMARCC1/BAF155 and SMARCD1/BAF60A in a DPF3a-dependent manner (PubMed:32459350).
More Types Infomation
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA, IP
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For Research Use Only. Not For Clinical Use.