Intracellular
Cell type enhanced (Muller glia cells, Distal tubular cells, Adipocytes)
Immune cell enhanced (neutrophil)
Group enriched (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with STING1/MITA and disrupts its interaction with MAVS or TBK1. Interacts with EIF3E. (Microbial infection) Interacts (via TPR repeat 2) with E1 proteins of HPV types 11, 18 and 3; this interaction blocks E1 helicase activity and viral replication.
RNA-binding
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For Research Use Only. Not For Clinical Use.