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ITGB4
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Protein class
Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells, Basal respiratory cells, Gastric mucus-secreting cells, Distal enterocytes)
Immune cell specificity
Immune cell enhanced (plasmacytoid DC)
Cell line specificity
Cell line enhanced (CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
Interaction
Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6. Interacts (via cytoplasmic region) with COL17A1 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus). Isoform beta-4a interacts (via cytoplasmic domain) with DST (via N-terminus). Interacts with RAC1. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3 (PubMed:20682778). ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R (PubMed:22351760). ITGA6:ITGB4 interacts with IGF2 (PubMed:28873464).
Molecular function
Integrin, Receptor
More Types Infomation
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC
-
- Species Reactivity: Human
- Application: ELISA, WB, ICC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, FC, IF
- Recombinant Mouse Anti-ITGB4 Antibody (UM-A9) (NEUT-1602CQ)
-
- Species Reactivity: Human
- Type: IgG2a, κ
- Application: FC, ICC/IF, BL
-
- Derivation: Rabbit
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, FC, IF, IHC-Fr, IP, WB, ICC
- Human Anti-ITGB4 Recombinant Antibody (clone L001) (HPAB-1275-FY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: IHC, FC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
- Human Anti-ITGB4 Recombinant Antibody (clone L001); scFv Fragment (HPAB-1275-FY-F(E))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: IHC, FC
- Recombinant Mouse Anti-ITGB4 Antibody (UMA9) (FN-067CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, FuncS, WB
- Chicken Anti-ITGB4 Polyclonal IgY (BRD-0300MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
- Human Anti-ITGB4 Recombinant Antibody (clone L001); Fab Fragment (HPAB-1275-FY-S(P))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: IHC, FC
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For Research Use Only. Not For Clinical Use.