Disease related genes, Human disease related genes
Intracellular, Membrane (different isoforms)
Cell type enhanced (Langerhans cells)
Immune cell enriched (neutrophil)
Low cell line specificity
Monomer (PubMed:27927196). Interacts with NEDD4 (PubMed:16118794, 27927196). Interacts (via PSAP motif) with TSG101, a component of the ESCRT-I complex (endosomal sorting complex required for transport I) (PubMed:16118794). Interacts with WWOX (PubMed:15064722). Interacts with STAM, a component of the ESCRT-0 complex; the interaction is direct (PubMed:23166352). Identified in a complex with STAM and HGS; within this complex, interacts directly with STAM, but not with HGS (PubMed:23166352). Interacts with STAT6 (PubMed:15793005).
DNA-binding
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For Research Use Only. Not For Clinical Use.