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NFAT5
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (SiHa)
Interaction
Homodimer when bound to DNA, completely encircles its DNA target. Interacts with CIDEC; this interaction is direct and retains NFAT5 in the cytoplasm (By similarity). Does not bind with Fos and Jun transcription factors. Interacts with DDX5 and DDX17; this interaction leads to DDX5/DDX17 recruitment to LNC2 and S100A4 promoters and NFAT5-mediated DDX5/DDX17-enhanced transactivation (PubMed:22266867).
Molecular function
Activator, DNA-binding
More Types Infomation
Related Signaling Pathways
BCR Signaling Pathway
cAMP Signaling Pathway
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IP
- Mouse Anti-NFAT5 Recombinant Antibody (clone 1D6) (VS3-WK1588)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: IHC-P, WB
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For Research Use Only. Not For Clinical Use.