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NMI
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
Protein class
Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (NB-4)
Interaction
Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif (PubMed:8668343). Interacts with all STAT proteins except STAT2 (PubMed:9989503). Interacts with IRF7, the interaction is direct and leads to the inhibition of IRF7-mediated type I IFN production (By similarity). Interacts (via coiled-coil domain) with TRIM21 (via the SPRY domain); the interaction leads to 'Lys-63'-linked ubiquitination of NMI (PubMed:26342464). Interacts with IFI35; the interaction is direct and is facilitated by TRIM21 (PubMed:10779520, PubMed:10950963, PubMed:26342464). Interacts with TLR4; the interaction is direct and leads to NF-kappa-B activation (PubMed:29038465). (Microbial infection) Interacts with human cytomegalovirus protein UL23; this interaction inhibits NMI-mediated transcription of interferon-gamma stimulated genes.
More Types Infomation
- Recombinant Mouse Anti-Human NMI Antibody (MOB-2231MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
- Mouse Anti-NMI Recombinant Antibody (VS3-WK927) (VS3-WK927)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.