Intracellular
Group enriched (Spermatocytes, Spermatogonia, Early spermatids)
Not detected in immune cells
Cell line enhanced (BEWO, CAPAN-2, MCF7, U-2 OS)
Component of the subcortical maternal complex (SCMC), at least composed of NLRP5, KHDC3L, OOEP, and TLE6 isoform 1 (PubMed:26537248, PubMed:25542835). Within the complex, interacts with NLRP5, KHDC3L and TLE6 isoform 1 (PubMed:26537248, PubMed:25542835). As part of the SCMC interacts with the SCMC-associated protein NLRP4F (By similarity). The SCMC may facilitate translocation of its components between the nuclear and cytoplasmic compartments (PubMed:25542835). Forms a scaffold complex with KHDC3L/FILIA, and interacts with BLM and TRIM25 at DNA replication forks (By similarity).
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For Research Use Only. Not For Clinical Use.