Plasma proteins, Transporters
Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis (PubMed:7819259, PubMed:9428644). Interacts with KPNB1 (PubMed:8896452, PubMed:9428644, PubMed:10367892). Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity (PubMed:9428644). Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP (PubMed:1961752, PubMed:7819259, PubMed:12194828, PubMed:11336674). Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP (PubMed:8896452). Interacts (GTP-bound form) with TNPO1; the interaction is direct (PubMed:9351834). Interacts (GTP-bound form) with TNPO3; the interaction is direct (PubMed:23878195, PubMed:24915079, PubMed:24449914). Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity (PubMed:8896452, PubMed:9428644). Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity (PubMed:7891706, PubMed:8896452, PubMed:9428644, PubMed:11832950). Interacts with RANGRF, which promotes the release of bound guanine nucleotide (PubMed:29040603). RANGRF and RCC1 compete for an overlapping binding site on RAN (PubMed:29040603). Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex (PubMed:9428644). Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1 (PubMed:9428644). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860). Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644). Identified in a nuclear export complex with XPO1 (PubMed:9323133, PubMed:15574331, PubMed:10209022). Found in a nuclear export complex with RANBP3 and XPO1 (PubMed:11571268, PubMed:11425870). Interacts with RANBP2/NUP358 (PubMed:10078529, PubMed:26272610). Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1 (PubMed:10209022, PubMed:19389996). Found in a nuclear export complex with RAN, XPO5 and pre-miRNA (By similarity). Interacts (GTP-bound form) with XPO5 (By similarity). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 (PubMed:14500717). Interacts with RANBP9 and RANBP10 (PubMed:14684163). Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle (PubMed:18591255). Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus (PubMed:12808100). Interacts with MAD2L2 (PubMed:19753112). Interacts with VRK1 and VRK3 (PubMed:18617507). Interacts with isoform 1 and isoform 2 of VRK2 (PubMed:18617507). Interacts with NEMP1 and KPNB1 (By similarity). Interacts (GDP-bound form) with NUTF2; regulates RAN nuclear import (PubMed:9822603, PubMed:10679025, PubMed:18266911). Interacts with CAPG; mediates CAPG nuclear import (PubMed:10679025, PubMed:18266911). Interacts with NUP153 (PubMed:18611384, PubMed:19505478). Interacts with the AR N-terminal poly-Gln region; the interaction with AR is inversely correlated with the poly-Gln length (PubMed:10400640). Interacts with MYCBP2, which promotes RAN-mediated GTP hydrolysis (PubMed:26304119). Interacts with EPG5 (PubMed:29130391). (Microbial infection) In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. (Microbial infection) Found in a complex with HTLV-1 Rex, RANBP3 and XPO1. (Microbial infection) Interacts with Mengo encephalomyocarditis virus Leader protein; the complex L-RAN recruits cellular kinases responsible for the L-induced nucleocytoplasmic trafficking inhibition.
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.