Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Intracellular, Membrane (different isoforms)
Cell type enriched (Alveolar cells type 2)
Not detected in immune cells
Group enriched (GAMG, HSkMC, hTCEpi, LHCN-M2)
Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity). Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation.
Kinase, Receptor, Transferase, Tyrosine-protein kinase
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For Research Use Only. Not For Clinical Use.