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SERPING1
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
Protein class
Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Hepatocytes, Fibroblasts, Leydig cells, Cholangiocytes, Ductal cells)
Immune cell specificity
Immune cell enhanced (neutrophil, plasmacytoid DC)
Cell line specificity
Group enriched (ASC diff, ASC TERT1, HSkMC)
Interaction
Binds to E. coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Interacts with MASP1.
Molecular function
Protease inhibitor, Serine protease inhibitor
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, FuncS, ICC/IF, IHC-Fr, IHC-P, IP, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, IHC, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.