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SLA2
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (dendritic cells, T-cells, NK-cells, Plasma cells, Macrophages)
Immune cell specificity
Group enriched (plasmacytoid DC, NK-cell, T-reg, naive CD8 T-cell, gdT-cell, memory CD8 T-cell, MAIT T-cell, memory CD4 T-cell, naive CD4 T-cell)
Cell line specificity
Group enriched (HEL, JURKAT)
Interaction
Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL (phosphorylated).
More Types Infomation
- Recombinant Mouse Anti-Human SLA2 Antibody (MOB-1549MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC/IF, IP, FC
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For Research Use Only. Not For Clinical Use.