Loading...
SLC1A1
This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Oligodendrocyte precursor cells, Proximal enterocytes, Glandular and luminal cells, Hepatocytes, Microglial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC TERT1, HDLM-2, HUVEC TERT2, RPTEC TERT1)
Interaction
Homotrimer (Probable). Interacts with ARL6IP5. Interacts with RTN2 (via N-terminus); the interaction promotes cell surface expression of SLC1A1. Interacts with SORCS2; this interaction is important for normal expression at the cell membrane (By similarity).
More Types Infomation
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IP
-
- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.