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SOCS3
SOCS3 is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity and thereby suppressing cytokine signaling. It is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. The expression of the SOCS3 gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. Studies of the mouse counterpart of the SOCS3 gene suggested this gene is involved in the negative regulation of fetal liver hematopoiesis, and placental development.
Protein class
Disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, Endothelial cells, Skeletal myocytes, Fibroblasts, Smooth muscle cells, Langerhans cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (HDLM-2, HSkMC, U-266/70)
Interaction
Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain (PubMed:10421843). Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors (PubMed:12027890, PubMed:14559241). Interaction with CSNK1E stabilizes SOCS3 protein (PubMed:15070676). Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3 (PubMed:15601820). Interacts with CUL5, RNF7, ELOB and ELOC (PubMed:15601820). Interacts with CUL2 (PubMed:15601820). Interacts with FGFR3 (PubMed:16410555). Interacts with INSR (By similarity). Interacts with BCL10; this interaction may interfere with BCL10-binding with PELI2 (By similarity). Interacts with NOD2 (via CARD domain); the interaction promotes NOD2 degradation (PubMed:23019338).
Molecular function
Signal transduction inhibitor
More Types Infomation
Related Signaling Pathways
TNF Signaling Pathway
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, IP, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA, IHC
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.