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SYT11
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]
Predicted location
Intracellular
Single cell type specificity
Group enriched (Muller glia cells, Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Astrocytes, Horizontal cells, Excitatory neurons, Bipolar cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Karpas-707, SCLC-21H, SH-SY5Y, U-87 MG)
Interaction
Homodimer. Can also form heterodimers. Interacts with PRKN (PubMed:12925569). Interacts (via C2 2 domain) with AGO2 and SND1; the interaction with SND1 is direct. Interacts with KIF1A; the interaction increases in presence of calcium (By similarity).
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.